- Biomodels
- Neurobiochemistry
lab
- Neuroimmunology
lab
- Molecular
biology lab
- Neural
tissue culture lab
- Morphology
lab
- Experimental
electrophysiology
- Department
of electroencephalography
- Eeg video
telemetry unit
- Department
of evoked potentials
- Electromyography
and transcraneal magnetic stimulation department
- Vivarium
- Clinic
neurophysiology lab
Biomodels
Creation and conductual
evaluation of experimental models by motor and cognitive multiple
evaluation battery tests. It works on parkinsonian rats with 60HDA
and bilateral parkinsonism in non-human primates with MPTP.
Multiple animal models
of neurodegenerative diseases (Parkinson’s, Huntington Chorea
and Alzheimer) are developed and validated, thus characterizing
the activity of different structures within neuronal circuitries
involved in these diseases; the effect of lesions and possibles
approach as a the therapeutic target. Neurobiologic bases of brain
ageing are approached; also evidences of functional plasticity
in the aged brain as well as its impact as to the adapting success
from the cognitive and motor points of view.
It has variable complex
batteries for the study and evaluation of such referred models
of the motor activity; sensorimotor coordination; sensorial exploration,
as well as different cognitive demains in rodents and non human
primates with neurotoxic lesions or naturally aged. The forementioned
allows the rigorous evaluation of non-conventional restorative
procedures among which are cellular replacement therapy (different
cellular sources), neurotrophic therapy; induction of the neurogenesis
through thehandling of environmental conditions, training and
exercise. As part of the pre-clinical validation process, studies
of correlation aided by other brain microdyalisis laboratories
are conducted, as well as others on oxidative stress, levels of
neurotrophins, inmunologic profile, expressions of receptors,
neurotrophins, enzymes, etc, with the use of molecular biology
techniques, morphology, etc.
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